Clinical Features and Prognostic Factors for Primary Anaplastic Large Cell Lymphoma of the Central Nervous System: A Systematic Review

Cancers

Kazuki Taoka¹  Mineo Kurokawa¹  Yudai Hirano²  Satoru Miyawaki²  Shunsaku Takayanagi²  Shota Tanaka²  Yu Teranishi²  Hirokazu Takami²  Hiroki Hongo²  Nobuhito Saito² 

[1] Department of Hematology and Oncology, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan;Department of Neurosurgery, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan;

关键词: anaplastic large cell lymphoma;    anaplastic lymphoma kinase;    CD30;    central nervous system;    primary central nervous system lymphoma;    prognostic factors;   

DOI  :  10.3390/cancers13174358

来源: DOAJ

【 摘 要 】

Primary anaplastic large cell lymphoma (ALCL) of the central nervous system (CNS) is a subtype of primary CNS lymphoma (PCNSL). There are very few comprehensive reports on this extremely rare tumor. Therefore, it is necessary to investigate the clinical features and prognostic factors for primary ALCL of the CNS. We performed a systematic review of the published literature. Past cases were comprehensively searched using PubMed, Cochrane Library, and Web of Science. Clinical information, such as age, sex, anaplastic lymphoma kinase (ALK) status, lesion sites, treatment methods, and survivorship were extracted. Thirty-nine cases with information on ALK status and treatment course were identified. The average observation period was 13 months, and the overall 2-year survival rate was 58%. Univariate analyses showed a statistically significantly better prognosis among patients < 40 years of age (p = 0.039, HR 0.32 (0.11–0.95)) and in relation to ALK positivity (p = 0.010, HR 0.24 (0.08–0.71) and methotrexate treatment (p = 0.003, HR 0.17 (0.05–0.56)). Because of the sparsity of cases, it is necessary to accumulate cases in order to perform more detailed analyses.

【 授权许可】

Unknown