Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Molecules

Yang Gao¹  Liyi Geng¹  Vicky Ping Chen¹  Stephen Brimijoin¹ 

[1] Department of Molecular Pharmacology and Experimental Therapeutics, Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA;

关键词: butyrylcholinesterase;    adeno-associated virus (AAV)-8;    AAV-9;    AAV-PHP.B;    enzyme expression;    ghrelin;   

DOI  :  10.3390/molecules22071145

来源: DOAJ

【 摘 要 】

Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the peptide hormone ghrelin and its impact on hunger, obesity, and emotions. Here, we present and examine means of manipulating brain BChE levels by viral gene transfer, either regionally or globally, to modulate ghrelin signaling for long-term therapeutic purposes and to set the stage for exploring the neurophysiological impact of such an intervention.

【 授权许可】

Unknown