FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease

International Journal of Molecular Sciences

Takeshi Okanoue¹  Aya Takahashi²  Hiroyoshi Taketani²  Kanji Yamaguchi²  Shinya Okishio²  Seita Kataoka²  Yuya Seko²  Kohta Yano²  Masashi Takemura²  Keiichiroh Okuda²  Taichiro Nishikawa²  Atsushi Umemura²  Michihisa Moriguchi²  Naoki Mizuno²  Yoshito Itoh² 

[1] Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Osaka 5640013, Japan;Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan;

关键词: nonalcoholic fatty liver disease;    type 2 diabetes;    hepatic fibrosis;    pnpla3;   

DOI  :  10.3390/ijms21010171

来源: DOAJ

【 摘 要 】

Non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). The aim of this retrospective study was to determine the risk factors for progression of CKD in patients with biopsy-proven NAFLD including patatin-like phospholipase domain containing 3 (PNPLA3) polymorphism. A total of 344 patients with biopsy-proven NAFLD were enrolled consecutively in this study. Multivariate analysis identified males (odds ratio (OR) 5.46), age (per 1 year, OR 1.07), and FIB-4 index (≥1.30, OR 3.85) as factors associated with CKD. Of the 154 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min, 30 had a deterioration in CKD stage and 15 developed CKD after 3 years. Multivariate analysis identified diabetes mellitus (OR 2.44) as a risk factor for deterioration in CKD stage, while diabetes mellitus (OR 21.54) and baseline eGFR (per 1 mL/min OR 0.88) were risk factors for development of CKD. PNPLA3 did not affect the change in eGFR. In NAFLD patients, a high FIB-4 index was associated with CKD to increases in the index linked to reductions in eGFR. In order to prevent development of CKD, an appropriate therapy focusing on renal function is needed for NAFLD patients, especially those with diabetes.

【 授权许可】

Unknown