Neuromedin U: A Small Peptide in the Big World of Cancer

Cancers

Kamila Soboska¹  Ewelina Sochacka¹  Patrycja Przygodzka¹  Joanna Boncela¹ 

[1] Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa Str, 93-232 Lodz, Poland;

关键词: Neuromedin U;    NMU;    GPCR receptors;    cancer;   

DOI  :  10.3390/cancers11091312

来源: DOAJ

【 摘 要 】

Neuromedin U (NMU), a neuropeptide isolated from porcine spinal cord and named because of its activity as a rat uterus smooth muscle contraction inducer, is emerging as a new player in the tumorigenesis and/or metastasis of many types of cancers. Expressed in a variety of tissues, NMU has been shown to possess many important activities in the central nervous system as well as on the periphery. Along with the main structural and functional features of NMU and its currently known receptors, we summarized a growing number of recently published data from different tissues and cells that associate NMU activity with cancer development and progression. We ask if, based on current reports, NMU can be included as a marker of these processes and/or considered as a therapeutic target.

【 授权许可】

Unknown