Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres

Materials

Meili Shen¹  Nianfeng Jiang²  Minglong Yuan²  Renyu Yang²  Cui Yang²  Xiangyu Zheng²  Yi He²  Hongli Li²  Mingwei Yuan² 

[1] National and Local Joint Engineering Laboratory for Synthesis Technology of High Performance Polymer, Jilin University, Changchun 130012, China;National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials, Yunnan Minzu University, Kunming 650500, China;

关键词: total alkaloids from Alstonia scholaris leaves;    mPEG-PLA;    microspheres;    drug release;    biocompatibility;   

DOI  :  10.3390/ma12091457

来源: DOAJ

【 摘 要 】

Total alkaloids of Alstonia scholaris leaves (ASAs) are extracted from the lamp leaves, which have positive anti-inflammatory activity and remarkable effects in treating bronchitis. Due to its short half-life, we used a degradable mPEG-PLA to physically encapsulate the total alkali of the lamp stage, and prepared a sustained-release microsphere by double-emulsion method. The ASAs-loaded mPEG₁₀₀₀₀-PLA microspheres were screened for better performance by testing the morphology, average particle size, embedding rate and drug loading of different molecular weight mPEG-PLA microspheres, which can stably and continuously release for 15 days at 37 °C. The results of cytotoxicity and blood compatibility indicated that the drug-loaded microspheres have beneficial biocompatibility. Animal experiments showed that the drug-loaded microspheres had a beneficial anti-inflammatory effect. These results all indicated that mPEG-PLA is a controlled release carrier material suitable for ASAs.

【 授权许可】

Unknown