Increased risk of prediabetes among virally suppressed adults with HIV in Central Kenya detected using glycated haemoglobin and fasting blood glucose

Endocrinology, Diabetes & Metabolism

Nancy Puttkammer¹  Carey Farquhar¹  Anne Njoroge¹  Orvalho Augusto¹  Stephanie T. Page²  Christine Kigondu³  Margaret Oluka⁴ 

[1] Department of Global Health University of Washington Seattle Washington USA;Department of Medicine University of Washington Seattle Washington USA;Department of Pathology University of Nairobi Nairobi Kenya;Department of Pharmacology and Pharmacognosy University of Nairobi Nairobi Kenya;

关键词: HIV;    prediabetes;    type 2 diabetes;    viral suppression;   

DOI  :  10.1002/edm2.292

来源: DOAJ

【 摘 要 】

Abstract Aims As survival among people living with HIV (PLHIV) improves with universal HIV treatment, new strategies are needed to support management of co‐morbidities like type 2 diabetes (T2D). We assessed prediabetes and T2D prevalence and risk factors using haemoglobin A1c (HbA1c) among PLHIV on antiretroviral therapy (ART) in Central Kenya. Methods This cross‐sectional study, conducted at a rural and urban site, enrolled PLHIV aged ≥35 years on ART for at least 5 years. HbA1c was assayed using Cobas b 101®, a point‐of‐care device. HbA1c levels ≥6.5% were considered diagnostic of T2D. For pre‐diabetic HbA1c levels (5.7%–6.4%), participants were requested to return the following day for a fasting blood glucose (FBG) to rule out T2D. Risk factors were assessed using multivariable log‐binomial regression. Results Of the 600 completing study procedures, the prevalence of diabetes was 5% (30/600). Ten participants were known to have diabetes; thus, prevalence of newly diagnosed T2D was 3.4% (20/590). Prevalence of prediabetes (HbA1c 5.7%–6.4%) was 14.2% (84/590). Significant predictors of elevated HbA1c were increase in age (Prevalence ratio [PR]: 1.10, CI: 1.02, 1.18, p = .012), hypertension (PR: 1.43, CI: 1.07–2.3, p = .015), central adiposity (PR: 2.11, CI: 1.57–2.84, p < .001) and use of Efavirenz (PR: 2.09, CI: 1.48, 2.96, p < .001). Conclusion There is a high prevalence of prediabetes, a significant predictor of T2D, among PLHIV in Central Kenya. Point‐of‐care HbA1c may help identify PLHIV with prediabetes in a single screening visit and provide an opportunity for early intervention.

【 授权许可】

Unknown