Short-Term Effects of Air Pollution on Coronary Events in Strasbourg, France—Importance of Seasonal Variations

Medical Sciences

Thierry Reeb¹  Olivier Morel²  Laurence Jesel²  Marie Moitry³  Nicolas Meyer⁴  Erik Sauleau⁴  Marie Mielcarek⁴  Baptiste Vaudrey⁵  Thomas Bourdrel⁵  Benjamin Marchandot⁵  Patrick Ohlmann⁵  Pierre Robellet⁶ 

[1] association à but non lucratif agréée par le Ministère chargé de l’environnement, 67300 Schiltigheim, France;Clinique Rhéna, 67000 Strasbourg, France;Department of Public Health, Strasbourg University Hospital, 67091 Strasbourg, France;GMRC, Service de Santé Publique, Centre Hospitalier Universitaire de Strasbourg, 67091 Strasbourg, France;Pôle d’Activité Médico-Chirurgicale Cardio-Vasculaire, Nouvel Hôpital Civil, Centre Hospitalier Universitaire, Université de Strasbourg, 67091 Strasbourg, France;Pôle exploitation—Unité Surveillance réglementaire, ATMO Grand EST;

关键词: air pollution;    acute coronary syndrome;    NO₂;    PM_2.5;    PM₁₀;    seasonality;   

DOI  :  10.3390/medsci8030031

来源: DOAJ

【 摘 要 】

The aim of this study, is to investigate the effects of a short-term exposure to air pollutants, as assessed by Nitrogen dioxide (NO₂), Particulate Matter PM_2,5 and PM₁₀ concentrations, on coronary event onsets in Strasbourg, France. An observational, analytical, retrospective, epidemiological study was conducted in Strasbourg between 1 January 2012 and 31 December 2014. Higher daily coronary events rates were evidenced when NO₂ concentrations were measured above 40 µg/m³ (1.258 (95% CI 1.142–1.374) vs. 1.110 (95% CI 1.033–1.186); p = 0.015). The NO₂ concentration was higher than 30 µg/m³ for 677 days (61.8%). Higher daily coronary events rates were evidenced when NO₂ concentrations were measured above 30 µg/m³ (1.208 (95% CI 1.128–1.289) vs. 1.067 (95% CI 0.961–1.172) p = 0.009). A marked seasonality of NO₂, PM_2.5, and PM₁₀ concentrations characterized by an increase during winter and a decrease during the summer could be established. The seasonality of coronary events was evidenced simultaneously. After adjustments were made to account for the time and the month, no independent impact of NO₂, PM_2.5 or PM₁₀ on daily coronary events could be demonstrated.

【 授权许可】

Unknown