A comparison of clinical outcomes between vaccinated and vaccine-naive patients of COVID-19, in four tertiary care hospitals of Kerala, South India

Clinical Epidemiology and Global Health

Parvathy Balachandran¹  Chandrasekhar Janakiram¹  Sabarish Balachandran²  Manoj P. Jose³  Prinoj Varghese⁴  C. Rajan⁴  Dhanraj Saboo⁵  Beena K. Vasudevan⁶  Reshmi Ann Varkey⁶  Dipu T. Sathyapalan⁷  Merlin Moni⁷  Geetha R. Menon⁸  Mithun R. Murugan⁹  Sooraj S. Nair^1,10  Jaideep C. Menon^1,11  Amitava Banerjee^1,12 

[1] Amrita School of Dentistry, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India;Department of Emergency Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India;Department of General Medicine, Little Flower Hospital and Research Centre, Kerala, 683572, India;Department of General Medicine, Sree Narayana Institute of Medical Sciences, Kerala, 683594, India;Department of Medicine, Little Flower Hospital and Research Centre, Kerala, India;Department of Public Health, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India;Division of Infectious Diseases, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India;ICMR- National Institute of Medical Statistics, New Delhi, India;Internal Medicine, PRS Hospital, Thiruvananthapuram, Kerala, 695002, India;PRS Hospital, Killipalam, Thiruvananthapuram, Kerala, 695002, India;Preventive Cardiology Unit, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, 682041, India;Professor in Clinical Data Science and Honorary Consultant Cardiologist, Institute of Health Informatics, University College London, United Kingdom;

关键词: COVID-19;    Vaccine;    Coronavirus;    Vaccine-breakthrough infection;    Outcomes;   

DOI  :  

来源: DOAJ

【 摘 要 】

The problem considered: This multi-centric study analyzed data of COVID-19 patients and compared differences in symptomatology, management, and outcomes between vaccinated and vaccine-naive patients. Methods: All COVID-19 positive individuals treated as an in-or out-patient from the 1stMarch to 15th May 2021 in four selected study sites were considered for the study. Treatment details, symptoms, and clinical course were obtained from hospital records. Chi-square was used to test the association of socio-demographic and treatment variables with the vaccination status and binary logistic regression were used to obtain the odds ratio with a 95% confidence interval. Results: The analysis was of 1446 patients after exclusion of 156 with missing data of which males were 57.3% and females 42.7%. 346 were vaccinated; 189 received one dose and 157 both doses. Hospitalization was more in vaccinated (38.2% vs 27.4%); ICU admissions were less in vaccinated (3.5% vs 7.1%). More vaccinated were symptomatic (OR = 1.5); half less likely to be on non-invasive ventilation (OR = 0.5) while vaccine naive patients had 4.21 times the risk of death. Conclusion: Severe infection, duration of hospital stays, need for ventilation and death were significantly less among vaccinated when compared with vaccine naive patients.

【 授权许可】

Unknown