Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change

Vaccines

Graham Pawelec¹  Jacek M. Witkowski²  Alan A. Cohen³  Claudio Franceschi⁴  Guillaume Provost⁵  Serafim Rodrigues⁵  Katsuiku Hirokawa⁶  Mathieu Desroches⁷  Tamas Fulop⁸  Guy Lacombe⁸  Abedelouahed Khalil⁸  Anis Larbi⁹ 

[1] Department of Immunology, University of Tübingen, 72072 Tübingen, Germany;Department of Pathophysiology, Medical University of Gdansk, 80-210 Gdansk, Poland;Groupe de Recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC J1H 5N4, Canada;IRCCS Institute of Neurological Sciences of Bologna, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy;Ikerbasque, The Basque Foundation for Science, 48009 Bilbao, Spain;Institute of Health and Life Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan;MathNeuro Team, Inria Sophia Antipolis Méditerranée, CEDEX, 06902 Sophia Antipolis, France;Research Center on Aging, Geriatric Division, Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada;Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Singapore 138648, Singapore;

关键词: immunosenescence;    inflammaging;    vaccination;    influenza vaccine;    pneumococcal vaccine;    herpes–zoster vaccine;   

DOI  :  10.3390/vaccines10040607

来源: DOAJ

【 摘 要 】

Organismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as decreased vaccine responses in humans. The most often cited vaccine failure is seasonal influenza, but, while it is usually the case that the efficiency of this vaccine is lower in older than younger adults, this is not always true, and the reasons for the differential responses are manifold. Undoubtedly, changes in the innate and adaptive immune response with ageing are associated with failure to respond to the influenza vaccine, but the cause is unclear. Moreover, recent advances in vaccine formulations and adjuvants, as well as in our understanding of immune changes with ageing, have contributed to the development of vaccines, such as those against herpes zoster and SARS-CoV-2, that can protect against serious disease in older adults just as well as in younger people. In the present article, we discuss the reasons why it is a myth that vaccines inevitably protect less well in older individuals, and that vaccines represent one of the most powerful means to protect the health and ensure the quality of life of older adults.

【 授权许可】

Unknown