Translational Significance for Tumor Metastasis of Tumor-Associated Macrophages and Epithelial–Mesenchymal Transition

Frontiers in Immunology

Wenzhe Song¹  Roberta Mazzieri³  Glenda C. Gobe³  Tao Yang⁴ 

[1] Department of General Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China;Discipline of Pathology, The Western Sydney University, Sydney, NSW, Australia;Faculty of Medicine, Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, QLD, Australia;SydPath, St Vincent’s Hospital, Sydney, NSW, Australia;

关键词: tumor microenvironment;    tumor-associated macrophages;    epithelial–mesenchymal transition;    metastasis;    EMT;   

DOI  :  10.3389/fimmu.2017.01106

来源: DOAJ

【 摘 要 】

The tumor microenvironment determines development and progression of many cancers. Epithelial–mesenchymal transition (EMT) is fundamental to tumor progression and metastasis not only by increasing invasiveness but also by increasing resistance to cell death, senescence, and various cancer therapies; determining inflammation and immune surveillance; and conferring stem cell properties. It does this by enabling polarized epithelial cells to transform into cells with a mesenchymal, and therefore motile, phenotype. Tumor-associated macrophages (TAMs) are key cells of the tumor microenvironment that orchestrate the connection between inflammation and cancer. Activation of EMT often requires crosstalk between cancer cells and components of the local tumor microenvironment, including TAMs. In this review, clinical and experimental evidence is presented for control of TAMs in promoting cancer cell invasion and migration and their interaction with the EMT process in the metastatic cascade. The translational significance of these findings is that the signaling pathways that interconnect TAMs and EMT-modified cancer cells may represent promising therapeutic targets for the treatment of tumor metastasis.

【 授权许可】

Unknown