Synthesis of both enantiomers and the 13C derivative of CPI-2850, the major metabolite of Devimistat

Results in Chemistry

Zachary Stine¹  Poli Adi Narayana Reddy²  Joseph M. Salvino² 

[1] Barer Institute, Rafael Holdings, Inc. Philadelphia PA 19107, United States;Medicinal Chemistry and Program in, The Wistar Institute, Philadelphia, PA 19104, United States;

关键词: Devimistat;    CPI-613®;    CPI-2850;    Single enantiomers;    Enantioselective synthesis;   

DOI  :  

来源: DOAJ

【 摘 要 】

A practical synthesis of CPI-2850, the major metabolite of Devimistat (CPI-613® (6,8-bis-benzylsulfanyloctanoic acid)), has been developed to synthesize multigram quantities for enantiomeric separation. Using enantioenriched (S)-(−)-1,2,4-butanetriol pure (S)-CPI-2850 enantiomer was synthesized to identify the individual enantiomers after enantiomeric resolution. A slightly modified synthetic route was used to synthesize 13C-CPI-2850 useful for metabolic studies.

【 授权许可】

Unknown