Prospective study of atopic status in infants of the cohort in Tokyo, Japan

Allergology International

Naohiro Hohashi¹  Chieko Sugishita¹  Fusako Komoda²  Hiroshi Hayakawa²  Tsutomu Iwata²  Michie Honjou³  Noriko Hirakawa³  Kazuko Inoue⁴  Kaeko Yamasaki⁵  Tatsuko Miyakawa⁵  Toyoo Sakurayama⁵  Masae Koseki⁵ 

[1] Department of Family Nursing, Faculty of Medicine, University of Tokyo, Japan;Department of Pediatrics, Mejirodai Campus, Japan;Department of Pediatrics, Second Hospital of Tokyo Women's Medical College, Japan;Department of Pediatrics, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan;Department of Public Health and Health Centre, Office of Bunkyo-District, Japan;

关键词: atopic dermatitis;    atopy;    bronchial asthma;    cohort study;    infants;    risk factor;    Several risk factors for the development;   

DOI  :  10.2332/allergolint.46.221

来源: DOAJ

【 摘 要 】

Several risk factors for the development of allergic diseases are considered including, for example, the level of IgE in cord blood or in the peripheral blood of neonates and the antigenic effect of some foods that are ingested by both babies and mothers during pregnancy and during the lactation period. However, not all infants with atopic diathesis develop allergic diseases. To clarify the risk factors and the mechanism for developing allergic diseases, particularly bronchial asthma (BA), we prospectively investigated atopic diatheses and symptoms in children in a cohort using a questionnaire method. The factors correlated to development of allergic diseases, as a whole, at the age of 5–6 years were atopic family history and any allergic symptom at 4 months of age. However, not all subjects with atopic dermatitis developed BA later on. High levels of total IgE and positive IgE antibody against egg white were not risk factors for developing BA at the age of 5–6 years.

【 授权许可】

Unknown