Indications, feasibility, safety, and efficacy of CyberKnife radiotherapy for the treatment of olfactory groove meningiomas: a single institutional retrospective series

Radiation Oncology

Jianmin Liu¹  Anand Mahadevan²  Rafael Rojas³  Ekkehard M. Kasper³  Fred C. Lam⁴  Farhan A. Mirza⁵ 

[1] Department of Neurosurgery, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine;Department of Radiation Oncology, Geisinger Medical Group;Department of Radiology, Division of Neuroradiology, Beth Israel Deaconess Medical Center, Harvard Medical School;Division of Neurosurgery, Department of Surgery, Hamilton General Hospital, McMaster University Faculty of Health Sciences;Division of Neurosurgery, Kentucky Neuroscience Institute, University of Kentucky;

关键词: Olfactory groove meningiomas;    CyberKnife radiotherapy;    Stereotactic radiosurgery;    Fractionated stereotactic radiotherapy;    Hypofractionated stereotactic radiotherapy;   

DOI  :  10.1186/s13014-020-01506-6

来源: DOAJ

【 摘 要 】

Abstract Purpose To assess the safety and efficacy of CyberKnife® radiotherapy (CKRT) for the treatment of olfactory groove meningiomas (OGMs). Methods A retrospective review was performed of 13 patients with OGM treated with CKRT from September 2005 to May 2018 at our institution. Nine patients were treated primarily with CKRT, 3 for residual disease following resection, and 1 for disease recurrence. Results Five patients were treated with stereotactic radiosurgery (SRS), 6 with hypofractionated stereotactic radiotherapy (HSRT), and 2 with fractionated stereotactic radiotherapy (FSRT). The median tumor volume was 8.12 cm3. The median prescribed dose was 14.8 Gy for SRS, 27.3 Gy for HSRT, and 50.2 Gy for FSRT. The median maximal dose delivered was 32.27 Gy. Median post treatment follow-up was 48 months. Twelve of 13 patients yielded a 100% regional control rate with a median tumor volume reduction of 31.7%. Six of the 12 patients had reduced tumor volumes while the other 6 had no changes. The thirteenth patient had significant radiation-induced edema requiring surgical decompression. Twelve patients were alive and neurologically stable at the time of the review. One patient died from pneumonia unrelated to his CKRT treatment. Conclusions CKRT appears to be safe and effective for the treatment of OGMs.

【 授权许可】

Unknown