Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature

Biologics: Targets & Therapy

关键词: spondylarthritides;    glomerular disease;    proteinuria;    kidney biopsy;    anti-tnf-alpha agents;   

DOI  :  

来源: DOAJ

【 摘 要 】

Constantina A Bounia,1 Eftichia N Theodoropoulou,1 Stamatic-Nick C Liossis1,2 1Division of Rheumatology, Patras University Hospital, Patras, Greece; 2Department of Internal Medicine, University of Patras Medical School, Patras, GreeceCorrespondence: Stamatic-Nick C LiossisDiv. of Rheumatology, Patras University Hospital, GR 26500, Rion, Patras, GreeceTel [phone]Fax [phone]Email [e-mail]: Renal failure or acute/chronic kidney damage may present as a clinical manifestation of rheumatic diseases. In addition treatment with DMARDs or biologic drugs may induce nephrotoxicity. In this case-based review, we present two patients with SpA under anti-TNF-α treatment admitted to our hospital because of renal failure and proteinuria. We review previously published yet isolated cases of TNF-α blocker-induced glomerular disease in patients with SpA. Renal manifestations are occasionally seen in patients with ankylosing spondylitis and psoriatic arthritis with IgA nephropathy being the most common of them. Anti-TNF-α agents although reportedly used for the treatment of glomerular nephropathy as a disease manifestation, they have been considered responsible for provoking renal damage in some cases. A diagnostic approach for patients with SpA treated with anti-TNF-α agents presenting with renal manifestations is proposed herein.Keywords: spondylarthritides, glomerular disease, proteinuria, kidney biopsy, anti-TNF-alpha agents

【 授权许可】

Unknown