Primary lymphoma of the heart: difficulties in diagnosis and treatment

Терапевтический архив

Nina Vladimirovna Gagarina¹  Aleksandr Viktorovich Nedostup¹  S S Chernyy¹  Vladimir Dmitrievich Parshin¹  Mariya Pavlovna Troitskaya¹  Valentin Evgen'evich Sinitsyn¹  Marina Vladimirovna Noskova¹  Sergey Leonidovich Dzemeshkevich¹  Vsevolod Parisovich Sedov¹  M V Noskova²  S L Dzemeshkevich³  S S Cherny³  V D Parshin³  V P Sedov⁴  A V Nedostup⁴  N V Gagarina⁴  M P Troitskaya⁴  O V Blagova⁴  V E Sinitsyn⁵ 

[1] ;A.N. Bakulev Research Center for Cardiovascular Surgery;B.V. Petrovsky Russian Research Center for Surgery;I.M. Sechenov State First Moscow Medical University;Therapeutic and Rehabilitation Center;

关键词: malignant tumors of the heart;    primary lymphoma of the heart;    diffuse large b-cell lymphoma;    hypertrophic cardiomyopathy;    pulmonary artery stenosis;    cardioverter-defibrillator;   

DOI  :  

来源: DOAJ

【 摘 要 】

Primary lymphoma of the heart (non-Hodgkin's lymphoma primarily of B-cells affecting first the heart and pericardium) is a rare disease which accounts for 1.3-2.0% of all primary tumors of the heart. A case is reported of a 43-year-old male patient with a cardioverter-defibrillator implanted at the age of 38 years for management of ventricular tachycardia paroxysms and AB-block of the second-third degree. The patient also had hypertrophic cardiomyopathy, moderate pressure gradient on the pulmonary artery valve and pericardial effusion. Later he had two cardiac tamponades (serous punctuate). From the age of 42 years breathlessness, right ventricular wall thickness, right heart pressure and pulmonary artery pressure aggravated. The patient has undergone ballon plastic surgery of the pulmonary artery valve. At the age of 43 computed tomography detected massive tumor of the heart and mediastinum first diagnosed as sarcoma but later specified as lymphoma. Endobronchial biopsy specimens contained the tissue of diffuse large B-cell lymphoma, the liver and lymph nodes were also involved. After the first course of effective polychemotherapy (CHOP) the patient died of mesenterial thrombosis. Diagnostic difficulties and problems of treatment policy are discussed.

【 授权许可】

Unknown