Interplay of serum hepcidin with female sex hormones, metabolic syndrome, and abdominal fat distribution among premenopausal and postmenopausal women

The Egyptian Journal of Internal Medicine

Ahmed Abdelfadel Saedii¹  Mohamed Emad AbdElftah²  Mohamed Gaber Essawy³  Ragaa Abdelshaheed Matta⁴ 

[1] Department of Clinical Pathology, Faculty of Medicine, Minia University;Department of Internal Medicine, Faculty of Medicine, Minia University;Department of Radiodiagnosis, Faculty of Medicine, Minia University;Diabetes and Endocrinology Unit, Department of Internal Medicine, Faculty of Medicine, Minia University;

关键词: Postmenopausal state;    Reproductive cycle phase;    Hepcidin;    Abdominal fat;    Metabolic resistance;    Female sex hormones;   

DOI  :  10.1186/s43162-022-00098-9

来源: DOAJ

【 摘 要 】

Highlights • Postmenopausal state (PMS) and metabolic syndrome (MetS) are independent factors of high hepcidin. • Estrogen and progesterone are correlated with hepcidin but not explain its higher level in PMS. • Ferritin, insulin resistance, and MetS are main contributors of high hepcidin in PMS. • High hepcidin in luteal phase is attributed to ferritin and abdominal subcutaneous fat • Hepcidin levels linearly increase with number of Mets feature and it had high sensitivity for diagnosis of MetS

【 授权许可】

Unknown