In vitro anthelmintic and cytotoxic activities of extracts from the stem barks of Berlinia confusa (C. Hoyle) and identification of its active constituents

Journal of Saudi Chemical Society

Oluwafunmilayo Idowu¹  Adebayo Lasisi² 

[1] Department of Biological Sciences, University of Agriculture, Abeokuta, Ogun State, Nigeria;Department of Chemistry, University of Agriculture, Abeokuta, Ogun State, Nigeria;

关键词: Berlinia confusa;    Anthelmintic activity;    Cytotoxic activities;    Monoacylglyceride;    Fabaceae;    Leguminosae;   

DOI  :  10.1016/j.jscs.2011.11.016

来源: DOAJ

【 摘 要 】

Phytochemical investigation of EtOAc extract from the stem bark of Berlinia confusa yielded a new and two known polysaturated monoacylglycerides characterised as 1-O-docosanoyl-sn-glyceride (3), 1-O-(13-methyltetradecanoyl)-sn-glycerol (4) and 1-O-pentadecacanoyl-sn-glycerol (5); along with the known compounds betulinic acid (1) and sitosteryl-β-d-glucoside (2). The structures of these compounds were elucidated using analytical methods, including 1D and 2D-NMR together with MS spectroscopy. The extracts and isolated compounds demonstrated concentration-dependent anthelmintic activities against Fusciola gigantica (liver flukes) and Taenia solium (tapeworm) at 10–100 mg/ml. The extracts and isolated compounds were evaluated for cytotoxicity against a small panel of three human tumour cell lines.

【 授权许可】

Unknown