Integrated head and neck imaging of symptomatic patients with stroke using simultaneous non-contrast cardiovascular magnetic resonance angiography and intraplaque hemorrhage imaging as compared with digital subtraction angiography

Journal of Cardiovascular Magnetic Resonance

Shuo Chen¹  Jiazheng Wang²  Lei Zhang³  Xiangchuang Kong⁴  Jing Wang⁴  Shenglei Shu⁴  Heshui Shi⁴  Yuxi Jia⁴  Lan Zhang⁴  Dingxi Liu⁴  Xiaoming Liu⁴  Jia Liu⁴  Xiaona Fu⁴ 

[1]Center for Biomedical Imaging Research, Tsinghua University School of Medicine

[2]Clinical & Technical Solutions, Philips Healthcare

[3]Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

[4]Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

关键词: SNAP;    Stroke;    Integrated head and neck vessel wall imaging;    Clinical factors;    Intraplaque hemorrhage;    Digital subtraction angiography;   

DOI  :  10.1186/s12968-022-00849-1

来源: DOAJ

【 摘 要 】

Abstract Background Both stenosis rate and intraplaque hemorrhage (IPH) are important predictors of stroke risk. Simultaneous non-contrast angiography and intraplaque hemorrhage (SNAP) cardiovascular magnetic resonance (CMR) imaging can detect both stenosis rate and IPH. We aimed to evaluate consistency between SNAP and digital subtraction angiography (DSA) to assess symptomatic patients with stroke and explore the performance of SNAP to identify IPH and the clinical factors associated with IPH. Methods Eighty-one symptomatic patients with stroke, admitted to Wuhan Union Hospital who underwent CMR high-resolution vessel wall imaging (HR-VWI) and SNAP, were retrospectively identified. For patients who received interventional therapy, the imaging functions of SNAP and HR-VWI were compared with DSA. The diameters of the intracranial and carotid vessels were measured, and stenotic vessels were identified. The consistency of SNAP and HR-VWI in identifying IPH was also examined, and the correlations between IPH and clinical factors were analyzed. Results SNAP was more consistent with DSA than HR-VWI in measuring vascular stenosis (intraclass correlation coefficient [ICC]SNAP-DSA = 0.917, ICC HR-VWI-DSA = 0.878). Regarding the diameter measurements of each intracranial and carotid vessel segment, SNAP was superior or similar to HR-VWI, and both were consistent with DSA in the measurement of major intracranial vascular segments. HR-VWI and SNAP exhibited acceptable agreement in identifying IPH (Kappa = 0.839, 95% confidence interval [CI]: 0.704–0.974). Patients who underwent interventional therapy had a higher plaque burden (P < 0.001). Patients with IPH had lower levels of high-density lipoprotein cholesterol (HDL) (P = 0.038) and higher levels of blood glucose (P = 0.007) and cystatin C (P = 0.040). Conclusions CMR SNAP is consistent with DSA in measuring vessel diameters and identifying atherosclerosis stenosis in each intracranial and carotid vessel segment. SNAP is also a potential alternative to HR-VWI in identifying stenosis and IPH.

【 授权许可】

Unknown