Recent developments in synthetic biology and metabolic engineering in microalgae towards biofuel production

Biotechnology for Biofuels

Sheeja Jagadevan¹  Chandan Guria¹  Avik Banerjee¹  Chiranjib Banerjee¹  Mehak Baweja²  Pratyoosh Shukla²  Rameshwar Tiwari² 

[1] Department of Environmental Science and Engineering, Indian Institute of Technology (Indian School of Mines);Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology, Maharshi Dayanand University;

关键词: Synthetic biology;    Microalgae;    Biofuel;    Optimization models;    Genome-scale reconstruction;    Biorefinery;   

DOI  :  10.1186/s13068-018-1181-1

来源: DOAJ

【 摘 要 】

Abstract In the wake of the uprising global energy crisis, microalgae have emerged as an alternate feedstock for biofuel production. In addition, microalgae bear immense potential as bio-cell factories in terms of producing key chemicals, recombinant proteins, enzymes, lipid, hydrogen and alcohol. Abstraction of such high-value products (algal biorefinery approach) facilitates to make microalgae-based renewable energy an economically viable option. Synthetic biology is an emerging field that harmoniously blends science and engineering to help design and construct novel biological systems, with an aim to achieve rationally formulated objectives. However, resources and tools used for such nuclear manipulation, construction of synthetic gene network and genome-scale reconstruction of microalgae are limited. Herein, we present recent developments in the upcoming field of microalgae employed as a model system for synthetic biology applications and highlight the importance of genome-scale reconstruction models and kinetic models, to maximize the metabolic output by understanding the intricacies of algal growth. This review also examines the role played by microalgae as biorefineries, microalgal culture conditions and various operating parameters that need to be optimized to yield biofuel that can be economically competitive with fossil fuels.

【 授权许可】

Unknown