Intracellular Cholesterol Synthesis and Transport

Frontiers in Cell and Developmental Biology

Qingyang Shi¹  Xiaochun Tang²  Xiaodong Zou³  Jiahuan Chen³ 

[1] Center of Reproductive Medicine and Center of Prenatal Diagnosis, The First Hospital, Jilin University, Changchun, China;Chongqing Research Institute of Jilin University, Chongqing, China;Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun, China;

关键词: cholesterol synthesis;    cholesterol trafficking;    intracellular;    endoplasmic reticulum;    sterol regulatory element-binding proteins;   

DOI  :  10.3389/fcell.2022.819281

来源: DOAJ

【 摘 要 】

Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export. In this review, we focus on de novo cholesterol synthesis, cholesterol synthesis regulation, and intracellular cholesterol trafficking. In addition, the progression of lipid transfer proteins (LTPs) at multiple contact sites between organelles is considered.

【 授权许可】

Unknown