Echocardiographic Normal Reference Ranges for Non-invasive Myocardial Work Parameters in Pediatric Age: Results From an International Multi-Center Study

Frontiers in Cardiovascular Medicine

Ciro Indolfi¹  Salvatore De Rosa¹  Valeria Pergola²  Sabrina La Bella⁴  Isabella Leo⁴  Antonio Strangio⁴  Alain Fraisse⁶  Josefa Paredes⁶  Jolanda Sabatino⁶  Enrico Piccinelli⁶  Domenico Sirico⁶  Giovanni Di Salvo⁶  Manjit Josen⁶  Martina Avesani⁶  Nunzia Borrelli⁶ 

[1] Cardiovascular Research Center, Magna Graecia University, Catanzaro, Italy;Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Padua, Italy;Department of Paediatric Cardiology, Royal Brompton Hospital, London, United Kingdom;Division of Cardiology, Department of Medical and Surgical Science, Magna Graecia University, Catanzaro, Italy;Division of Paediatric Cardiology, Department of Women's and Children's Health, University Hospital Padua, Padua, Italy;National Heart and Lung Institute, Imperial College, London, United Kingdom;Pediatric Research Institute (IRP) “Città della Speranza”, Padua, Italy;

关键词: myocardial work indices;    advanced echocardiography;    speckle tracking analysis;    systolic function;    congenital heart disease;   

DOI  :  10.3389/fcvm.2022.792622

来源: DOAJ

【 摘 要 】

AimsThis international multi-center study aimed to demonstrate the feasibility and reliability of non-invasive myocardial work (MW) parameters in the pediatric population, and to provide normal reference ranges for this useful echocardiographic tool in this specific subset of patients.Methods and ResultsIn this retrospective multi-center study involving three pediatric laboratories, 150 healthy children and adolescents (mean age of 10.6 ± 4.5, 91 males) were enrolled. A complete echocardiographic examination has been performed, including global longitudinal strain (GLS) assessment. The following parameters of non-invasive MW have been obtained through a dedicated software: global work index (GWI), global constructive work (GCW), global work waste (GWW), and global work efficiency (GWE), using left ventricular (LV) strain loops and non-invasive brachial artery cuff pressure values. The lowest expected values were for GWI 1,723 mmHg% in males and 1,682 mmHg% in females, for GCW 2,089 and 2,106 mmHg%, for GWE 95.9 and 95.5% whereas the highest expected value for GWW was 78 mmHg% in men and 90 mmHg% in women. The univariable and multivariable analysis showed significant associations between either GWI or GCW with SBP (β coefficient = 0.446, p < 0.001; β coefficient = 0.456, p < 0.001, respectively) and LV GLS (β coefficient = −0.268, p = 0.001; β coefficient = −0.233, p = 0.003, respectively). Inter- and intra-observer variability showed good reproducibility of non-invasive MW parameters.ConclusionNon-invasive MW parameters were feasible and reliable in the pediatric population. This study provided normal reference ranges of these useful echocardiographic indices.

【 授权许可】

Unknown