The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A

Journal of Neuroinflammation

Xi Liu¹  Jiajia Fu²  Xueping Chen²  Yan Huang³  Ting Bao³  Chengcheng Liu⁴ 

[1] Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University;Department of Neurology, West China Hospital, Sichuan University;Management Center, West China Hospital, Sichuan University;State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University;

关键词: TH17;    IL-17A;    Alzheimer’s disease;    Parkinson’s disease;    Amyotrophic lateral sclerosis;    Targeted therapy;   

DOI  :  10.1186/s12974-022-02446-6

来源: DOAJ

【 摘 要 】

Abstract Neurodegenerative diseases are a group of disorders characterized by progressive loss of certain populations of neurons, which eventually lead to dysfunction. These diseases include Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Immune pathway dysregulation is one of the common features of neurodegeneration. Recently, there is growing interest in the specific role of T helper Th 17 cells and Interleukin-17A (IL-17A), the most important cytokine of Th 17 cells, in the pathogenesis of the central nervous system (CNS) of neurodegenerative diseases. In the present study, we summarized current knowledge about the function of Th17/IL-17A, the physiology of Th17/IL-17A in diseases, and the contribution of Th17/IL-17A in AD, PD, and ALS. We also update the findings on IL-17A-targeting drugs as potentially immunomodulatory therapeutic agents for neurodegenerative diseases. Although the specific mechanism of Th17/IL-17A in this group of diseases is still controversial, uncovering the molecular pathways of Th17/IL-17A in neurodegeneration allows the identification of suitable targets to modulate these cellular processes. Therapeutics targeting IL-17A might represent potentially novel anti-neurodegeneration drugs.

【 授权许可】

Unknown