Exploring the Potential Targets and Mechanisms of Huang Lian Jie Du Decoction in the Treatment of Coronavirus Disease 2019 Based on Network Pharmacology

International Journal of General Medicine

关键词: huang lian jie du decoction;    coronavirus disease 2019;    covid-19;    sars-cov-2;    network pharmacology;    traditional chinese medicine;   

DOI  :  

来源: DOAJ

【 摘 要 】

Wang Liu,1,* Yu Zeng,1,* Yanda Li,2,* Nanhong Li,3 Min Peng,1 Junfen Cheng,1 Binbin Tian,4 Mingdi Chen5 1Department of Respiration, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China; 2Department of Internal Medicine, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong, People’s Republic of China; 3Department of Pathology and Pathophysiology, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 4Department of Critical Care Medicine, Central People’s Hospital of Zhanjiang, Zhanjiang, Guangdong, People’s Republic of China; 5Department of Critical Care Medicine, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mingdi Chen; Binbin Tian Email [e-mail]; [e-mail]: In December 2019, coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2; previously known as 2019-nCoV) emerged in Wuhan, China, and caused many infections and deaths. At present, there are no specific drugs for the etiology and treatment of COVID-19. A combination of traditional Chinese and western medicine is proposed to treat COVID-19, in which Huang Lian Jie Du decoction (HLJDD) is recommended for the treatment of COVID-19 in many provinces in China and has been widely used in the clinic. This study explored the potential targets of HLJDD in the treatment of COVID-19 based on network pharmacology.Methods: First, the chemical composition and targets of HLJDD and COVID-19-related targets were obtained through the TCMSP, UniProt, GeneCards and OMIM databases. Second, HLJDD target and HLJDD-COVID-19 target networks were constructed via the STRING database and Cytoscape software. Finally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the HLJDD-COVID-19 targets was applied via the DAVID database.Results: Our study identified a total of 67 active ingredients of HLJDD and 204 targets of HLJDD. A total of 502 COVID-19-related targets were obtained, of which 47 were intersecting targets of HLJDD and COVID-19. A total of 179 GO terms and 77 KEGG terms, including the TNF signaling pathway, NF-κB signaling pathway and HIF-1 signaling pathway, were identified.Conclusion: The present study explored the potential targets and signaling pathways of HLJDD during the treatment of COVID-19, which may provide a basis for the research and development of drugs for the treatment of COVID-19.Keywords: Huang Lian Jie Du decoction, coronavirus disease 2019, COVID-19, SARS-CoV-2, network pharmacology, traditional Chinese medicine

【 授权许可】

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