Spontaneous mutations and the origin and maintenance of quantitative genetic variation

eLife

Michael M Magwire¹  Rachel A Lyman¹  Richard F Lyman²  Susan T Harbison²  Wen Huang³  Trudy FC Mackay³  Mary Anna Carbone³ 

[1] Department of Biological Sciences, North Carolina State University, Raleigh, United States;W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, United States;Program in Genetics, North Carolina State University, Raleigh, United States;

关键词: mutation accumulation;    genome sequencing;    gene expression;    stabilizing selection;   

DOI  :  10.7554/eLife.14625

来源: DOAJ

【 摘 要 】

Mutation and natural selection shape the genetic variation in natural populations. Here, we directly estimated the spontaneous mutation rate by sequencing new Drosophila mutation accumulation lines maintained with minimal natural selection. We inferred strong stabilizing natural selection on quantitative traits because genetic variation among wild-derived inbred lines was much lower than predicted from a neutral model and the mutational effects were much larger than allelic effects of standing polymorphisms. Stabilizing selection could act directly on the traits, or indirectly from pleiotropic effects on fitness. However, our data are not consistent with simple models of mutation-stabilizing selection balance; therefore, further empirical work is needed to assess the balance of evolutionary forces responsible for quantitative genetic variation.

【 授权许可】

Unknown