Prognostic Value of Pretreatment Prognostic Nutritional Index in Patients With Renal Cell Carcinoma: A Meta-Analysis

Frontiers in Oncology

Chun Wang¹  Jun Yan¹  Weixin Xu¹  Weina Ma²  Changqing Mao³  Zhaojiao Guo⁴ 

[1] Health Sciences, Shanghai, China;;Department of Laboratory Medicine, Jiading District Central Hospital Affiliated Shanghai University of Medicine &;Department of Nephrology, Jiading District Central Hospital Affiliated Shanghai University of Medicine &;Department of Pharmacy, Jiading District Central Hospital Affiliated Shanghai University of Medicine &

关键词: PNI;    renal cell carcinoma;    meta-analysis;    prognosis;    immune responses;   

DOI  :  10.3389/fonc.2021.719941

来源: DOAJ

【 摘 要 】

BackgroundThe pretreatment prognostic nutritional index (PNI) is correlated with poor prognosis in several malignancies. However, the prognostic role of PNI in patients with renal cell carcinoma (RCC) remains unclear. Therefore, we performed a meta-analysis to investigate the prognostic significance of PNI in patients with RCC.MethodsWe searched the PubMed, Web of Science, Embase, Scopus, and Cochrane Library databases up to February 2021. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate correlation between PNI and survival endpoints in RCC.ResultsTen studies with 4,908 patients were included in the meta-analysis. The pooled results indicated that a low PNI associated with poor overall survival (HR = 2.10, 95% CI = 1.67–2.64, p<0.001), shorter progression-free survival, disease-free survival, recurrence-free survival (HR = 1.99, 95% CI = 1.67–2.36, p<0.001), and poor cancer-specific survival (HR = 2.95, 95% CI = 1.61–5.39, p<0.001). Additionally, the prognostic ability of PNI was not affected by subgroup analysis factors.ConclusionThe meta-analysis indicated that low PNI associated with shorter survival outcomes in patients with RCC. Therefore, PNI could be used as an effective prognostic indicator in RCC.

【 授权许可】

Unknown