Recent Advances in Antimicrobial Nano-Drug Delivery Systems

Nanomaterials

Luis Alexandre Muehlmann¹  Marina Carvalho Sampaio¹  José Athayde Vasconcelos Morais¹  Ariane Pandolfo Silveira¹  Juan Zhang²  Shan-Kui Liu²  Cheng-Shi Jiang²  Tong-Xin Zong² 

[1] Institute of Biological Sciences, University of Brasília, Brasilia 70910900, Brazil;School of Biological Science and Technology, University of Jinan, Jinan 250022, China;

关键词: antimicrobial;    antimicrobial resistance;    drug delivery systems;    nanoparticles;    nanocarriers;   

DOI  :  10.3390/nano12111855

来源: DOAJ

【 摘 要 】

Infectious diseases are among the major health issues of the 21st century. The substantial use of antibiotics over the years has contributed to the dissemination of multidrug resistant bacteria. According to a recent report by the World Health Organization, antibacterial (ATB) drug resistance has been one of the biggest challenges, as well as the development of effective long-term ATBs. Since pathogens quickly adapt and evolve through several strategies, regular ATBs usually may result in temporary or noneffective treatments. Therefore, the demand for new therapies methods, such as nano-drug delivery systems (NDDS), has aroused huge interest due to its potentialities to improve the drug bioavailability and targeting efficiency, including liposomes, nanoemulsions, solid lipid nanoparticles, polymeric nanoparticles, metal nanoparticles, and others. Given the relevance of this subject, this review aims to summarize the progress of recent research in antibacterial therapeutic drugs supported by nanobiotechnological tools.

【 授权许可】

Unknown