Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

Antibiotics

Maarten B. M. van Dongen¹  Maneesh Paul Satyaseela²  Jayaseelan Murugaiyan³  Saranya Adukkadukkam³  Yara Mohsen⁴  Bruno Tilocca⁵  Paola Roncada⁵  Katia Iskandar⁶  John P. Hays⁷  Oluwatosin O. Akinwotu⁸  Abishek Kumar⁹  P. Anand Kumar^1,10  G. Srinivasa Rao^1,11  Wireko Andrew Awuah^1,12  Abdul-Rahman Toufik^1,12  Stephen Hawser^1,13  Javier Moreno-Morales^1,14  Natalia Roson-Calero^1,14  Nanono Sylvia^1,15  Rohul Amin^1,16  Ballamoole Krishna Kumar^1,17  Thaint Nadi Zaw^1,18  Ruiz Alvarez Maria Jose^1,19  Esther Patience Nansubuga^2,20 

[1] AMR Insights, 1017 EG Amsterdam, The Netherlands;Acharya Institute of Technology, Soladevanahalli, Bengaluru 560107, India;Department of Biological Sciences, SRM University-AP, Guntur District, Amaravati 522240, India;Department of Epidemiology, High Institute of Public Health, Alexandria University, Alexandria 21544, Egypt;Department of Health Science, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy;Department of Mathématiques Informatique et Télécommunications, Université Toulouse III, Paul Sabatier, INSERM, UMR 1295, 31000 Toulouse, France;Department of Medical Microbiology, Infectious Diseases, Erasmus University Medical Centre (Erasmus MC), 3015 GD Rotterdam, The Netherlands;Department of Microbiology and Biotechnology Centre, Maharaja Sayajirao University of Baroda, Vadodara 390002, India;Department of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, India;Department of Veterinary Microbiology, NTR College of Veterinary Science, Sri Venkateswara Veterinary University, Gannavaram 521102, India;Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati 517502, India;Faculty of Medicine, Sumy State University, 40007 Sumy, Ukraine;IHMA Europe Sàrl, 1870 Monthey, Switzerland;ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain;Infectious Diseases Institute (IDI), College of Health Sciences, Makerere University, Kampala 7072, Uganda;James P Grant School of Public Health, BRAC University, Dhaka 1212, Bangladesh;Nitte (Deemed to be University), Division of Infectious Diseases, Nitte University Centre for Science Education and Research, Deralakatte, Mangalore 575018, India;Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK;Research Coordination and Support Service, National Institute of Health (ISS) Viale Regina -Elena, 299, 00161 Rome, Italy;School of Medicine, University of Leeds, Leeds LS2 9JT, UK;

关键词: antimicrobial resistance;    antibiotic resistance;    antibiotic alternatives;    enzyme inhibitors;    antimicrobial peptides;    bacteriophages;   

DOI  :  10.3390/antibiotics11020200

来源: DOAJ

【 摘 要 】

Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failure of conventional, traditional antimicrobial therapy, in the past two decades, no novel class of antibiotics has been introduced. Consequently, several novel alternative strategies to combat these (multi-) drug-resistant infectious microorganisms have been identified. The purpose of this review is to gather and consider the strategies that are being applied or proposed as potential alternatives to traditional antibiotics. These strategies include combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods, and unconventional techniques, including the CRISPR-Cas system. These alternative strategies may have the potential to change the treatment of multi-drug-resistant pathogens in human clinical settings.

【 授权许可】

Unknown