Wnt Signaling in Thyroid Homeostasis and Carcinogenesis

Genes

Lindsay A. Bischoff¹  Vivian L. Weiss²  Kim A. Ely² 

[1] Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA;Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA;

关键词: thyroid cancer;    Wnt signaling;    cancer stem cells;   

DOI  :  10.3390/genes9040204

来源: DOAJ

【 摘 要 】

The Wnt pathway is essential for stem cell maintenance, but little is known about its role in thyroid hormone signaling and thyroid stem cell survival and maintenance. In addition, the role of Wnt signaling in thyroid cancer progenitor cells is also unclear. Here, we present emerging evidence for the role of Wnt signaling in somatic thyroid stem cell and thyroid cancer stem cell function. An improved understanding of the role of Wnt signaling in thyroid physiology and carcinogenesis is essential for improving both thyroid disease diagnostics and therapeutics.

【 授权许可】

Unknown