Primordial Germ Cell Specification and Migration [version 1; referees: 3 approved]

F1000Research

Florence Marlow¹ 

[1] Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, 10461, USA;

关键词: Biocatalysis;    Biomacromolecule-Ligand Interactions;    Developmental Evolution;    Developmental Molecular Mechanisms;    Morphogenesis & Cell Biology;    Pattern Formation;    Protein Chemistry & Proteomics;    Protein Folding;    Stem Cells & Regeneration;   

DOI  :  10.12688/f1000research.6995.1

来源: DOAJ

【 摘 要 】

Primordial germ cells are the progenitor cells that give rise to the gametes. In some animals, the germline is induced by zygotic transcription factors, whereas in others, primordial germ cell specification occurs via inheritance of maternally provided gene products known as germ plasm. Once specified, the primordial germ cells of some animals must acquire motility and migrate to the gonad in order to survive. In all animals examined, perinuclear structures called germ granules form within germ cells. This review focuses on some of the recent studies, conducted by several groups using diverse systems, from invertebrates to vertebrates, which have provided mechanistic insight into the molecular regulation of germ cell specification and migration.

【 授权许可】

Unknown