Protective Effects of Nootkatone on Renal Inflammation, Apoptosis, and Fibrosis in a Unilateral Ureteral Obstructive Mouse Model

Nutrients

Kuo-Tong Huang¹  Cheng-Tien Wu²  Chia-Hung Liu³  Chang-Mu Chen⁴  Siao-Syun Guan⁵  Chen-Yu Lin⁶  Yao-Pang Chung⁶  Shing-Hwa Liu⁶ 

[1] Department of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 10051, Taiwan;Department of Nutrition, China Medical University, Taichung 406040, Taiwan;Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11041, Taiwan;Division of Neurosurgery, Department of Surgery, College of Medicine and Hospital, National Taiwan University, Taipei 10051, Taiwan;Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan 32546, Taiwan;Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan;

关键词: chronic kidney disease;    nootkatone;    inflammation;    apoptosis;    renal fibrosis;   

DOI  :  10.3390/nu13113921

来源: DOAJ

【 摘 要 】

Nootkatone is one of the major active ingredients of Alpiniae oxyphyllae, which has been used as both food and medicinal plants for the treatment of diarrhea, ulceration, and enuresis. In this study, we aimed to investigate whether nootkatone treatment ameliorated the progression of chronic kidney diseases (CKD) and clarified its underlying mechanisms in an obstructive nephropathy (unilateral ureteral obstructive; UUO) mouse model. Our results revealed that nootkatone treatment preventively decreased the pathological changes and significantly mitigated the collagen deposition as well as the protein expression of fibrotic markers. Nootkatone could also alleviate oxidative stress-induced injury, inflammatory cell infiltration, and renal cell apoptotic death in the kidneys of UUO mice. These results demonstrated for the first time that nootkatone protected against the progression of CKD in a UUO mouse model. It may serve as a potential therapeutic candidate for CKD intervention.

【 授权许可】

Unknown