Acute psychosis secondary to isoniazid in pediatric pulmonary tuberculosis: A case report and literature review

International Journal of Pediatrics and Adolescent Medicine

Sulaiman Al Alola¹  Moza Alhammadi²  Nadia Alattas³  Saleh Alfawaz³  Saadia Waqar⁴ 

[1] Corresponding author. Division of Pediatric Infectious Diseases, King Abdullah Specialized Children’s Hospital, National Guard Health Affairs, Riyadh, Saudi Arabia.;Division of Pediatric Infectious Diseases, King Abdullah Specialized Children’s Hospital (KASCH), National Guard Health Affairs, Riyadh, Saudi Arabia;College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia;Division of Pediatric Infectious Diseases, King Abdullah Specialized Children’s Hospital (KASCH), National Guard Health Affairs, Riyadh, Saudi Arabia;

关键词: INH-Induced psychosis;    Isoniazid;    Hallucinations;    Psychosis;    Tuberculosis;    Pediatrics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Isoniazid (INH) is a first-line tuberculosis (TB) drug and is currently recommended as part of active and latent TB treatment in all ages. INH adverse reactions range from mild hepatitis to severe neurological symptoms and psychosis. Since its introduction in the 1950s, many case reports have explored INH-induced psychosis. We describe a 12-year-old girl with acute onset hallucinations and delusions as a rare complication of INH and review previous case reports and identified risk factors. Pediatricians need to be aware of this less common side effect as they work through a differential of acute psychosis in children.

【 授权许可】

Unknown