Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery

Materials

Xujie Liu¹  Qiang Cai¹  Youwei Yao¹  Qingming Long¹  Yong Xie¹  Xinxin Ma²  Yu Wang³ 

[1] Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China;Southern China Branch, Sinopec Commercial Holding Company Limited, Guangzhou 510630, China;State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China;

关键词: carrier-free;    4-amino-2-benzyl-6-methylpyrimidine;    biomaterial;    drug delivery;   

DOI  :  10.3390/ma11020281

来源: DOAJ

【 摘 要 】

There are several challenges involved in the development of effective anti-cancer drugs, including accurate drug delivery without toxic side effects. Possible systemic toxicity and the rapid biodegradation of drug carriers are potential risks in the use of carriers for drug-delivery formulations. Therefore, the carrier-free drug delivery of an anti-cancer drug is desirable. Herein, 4-amino-2-benzyl-6-methylpyrimidine (ABMP) was synthesized via a new method using a sodium catalyst, and proved to be effective in inducing breast cancer cell (MDA-MB-231) apoptosis. Moreover, the transparent amorphous state solid of ABMP was demonstrated to have a slow-release property in phosphate buffer solution (PBS). Microspheres of ABMP were prepared with diameters in the range of 5–15 μm. The slow-release property of the ABMP microspheres indicated their potential use for controlled-release drug delivery. We believe that microspheres of ABMP have potential as a new kind of carrier-free anti-cancer drug delivery system.

【 授权许可】

Unknown