Narcolepsy in the light of modern diagnostic, clinical and therapeutic concepts

Journal of Education, Health and Sport

Alicja Nowaczyk¹  Magdalena Kowalska¹  Adrian Kowalski²  Wiktor Dróżdż²  Iwona Kowalska³ 

[1] Department of Organic Chemistry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń;II Clinic of Psychiatry, Collegium Medicum in Bydgoszcz,Nicolaus Copernicus University in Toruń;The Josef Brudzinski Provincial Children’s Hospital in Bydgoszcz;

关键词: narcolepsy;    cataplexy;    hypersomnia;    hypocretins;    orexins;    hla-dqb1*0602;    treatment of narcolepsy;   

DOI  :  10.5281/zenodo.1471651

来源: DOAJ

【 摘 要 】

Narcolepsy is a chronic neurological disease classified as hypersomnia of central origin. Core symptoms of the disease (hypersomnia and cataplexy) are particularly burdensome for patients. The etiology of the disease is not fully understood. There are several theories explaining the essence of the disease. One of the possible causes is the disruption of the autoimmune system leading to the disappearance of hypocretin-releasing neurons. Currently, multicenter studies on synthesizing hypocretin-like proteins that may be the basis of causal narcolepsy treatment are conducted. As yet pharmacotherapy contributes only to reduce the symptoms of the disease. Commonly used medications are amphetamine derivatives, modafinil, pitolisant and γ-hydroxybutyric acid sodium salt (GHB).

【 授权许可】

Unknown