Study of 8 Types of Glutathione Peroxidase Mimics Based on β-Cyclodextrin

Catalysts

Liwu Wang¹  Xiaonan Qu¹  Ying Xie¹  Shaowu Lv¹ 

[1] Key Laborabory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130023, China;

关键词: glutathione peroxidase;    mimic enzyme;    cyclodextrin derivatives;    enzyme activity;    kinetics;   

DOI  :  10.3390/catal7100289

来源: DOAJ

【 摘 要 】

Glutathione peroxidase is key for the removal of H2O2 and other hydroperoxides and therefore, it has an important role in the maintenance of the reactive oxygen species (ROS) metabolic balance in vivo. The native enzymes of the glutathione peroxidase family (GPx) have many defects, such as instability in vitro and poor availability. GPx mimetics has become a topic of considerable interest in artificial enzyme research. Many forms of GPx mimics have been synthesized, by including selenium and tellurium (double-bridged and single-bridged, 2-substituted and 6-substituted) in a mother molecule but differences the GPx mimics enzymatic activity have rarely been compared. We designed and synthesized eight cyclodextrin derivatives and used two types of enzyme assays to determine their activities. The results show that: (a) tellurium-containing GPx mimics have higher activity than that of selenium-containing GPx mimics; (b) dual-bridged mimics have higher activity than bis-bridged mimics; and (c) 2-position modified cyclodextrin has higher activity than 6-position modified cyclodextrin.

【 授权许可】

Unknown