Biophysical studies of cancer cells’ traverse-vessel behaviors under different pressures revealed cells’ motion state transition

Scientific Reports

Xin Li¹  Ziqing Gao²  Jian Xu³  Chunxiong Luo³  Shujing Wang³  Xiao Li³  Jialin Shi³  Qi Ouyang³ 

[1] Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University;Peking-Tsinghua Center for Life Sciences, Peking University;The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University;

DOI  :  10.1038/s41598-022-11047-5

来源: DOAJ

【 摘 要 】

Abstract Circulating tumor cells (CTCs) survive in the bloodstream and then seed and invade to foster tumor metastasis. The arrest of cancer cells is favored by permissive flow forces and geometrical constraints. Through the use of high-throughput microfluidic devices designed to mimic capillary-sized vessels, we applied pressure differences to cancer cells (MCF-7 cell line) and recorded the cell traverse-vessel behaviors. Our results showed that cancer cells transform from a Newtonian droplet state to an adhesion/migration state when cancer cells traverse artificial vessels. To explain these phenomena, a modified Newtonian droplet model was also proposed. These phenomena and the modified model may reveal how CTCs in the blood seed and invade vessels under suitable conditions.

【 授权许可】

Unknown