Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Cancer Cell International

Agnieszka Szopa¹  Praveen Dhyani²  William C. Cho³  Daniela Calina⁴  Eshita Sharma⁵  Ileana Mardare⁶  Anca Oana Docea⁷  Cristina Quispe⁸  Javad Sharifi-Rad⁹  Dharam Chand Attri^1,10  Amit Bahukhandi^1,10  Priyanka Sati^1,11 

[1] Chair and Department of Pharmaceutical Botany, Medical College, Jagiellonian University;Department of Biotechnology, Kumaun University;Department of Clinical Oncology, Queen Elizabeth Hospital;Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova;Department of Molecular Biology and Biochemistry, Guru Nanak Dev University;Department of Public Health and Management, Carol Davila University of Medicine and Pharmacy Bucharest;Department of Toxicology, University of Medicine and Pharmacy of Craiova;Facultad de Ciencias de la Salud, Universidad Arturo Prat;Facultad de Medicina, Universidad del Azuay;G.B. Pant National Institute of Himalayan Environment;Graphic Era University;

关键词: Alkaloids;    Vinca;    Catharanthus;    Colchicum;    Anticancer;    Microtubule-targeting agents;   

DOI  :  10.1186/s12935-022-02624-9

来源: DOAJ

【 摘 要 】

Abstract Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.

【 授权许可】

Unknown