Protein-ligand binding interactions of imidazolium salts with SARS CoV-2

Heliyon

Kasi Chithra¹  Annamalai Rajendran²  Dhurairaj Satheesh³ 

[1] Corresponding author.;PG and Research Department of Chemistry, Loganatha Narayanaswamy Government College (Autonomous), Ponneri 601 204, Tamilnadu, India;Research and Development Centre, Bharathiar University, Coimbatore 641 046, Tamilnadu, India;

关键词: Computational chemistry;    Organic chemistry;    Systems biology;    Bioinformatics;    Biotechnology;    Biochemistry;   

DOI  :  

来源: DOAJ

【 摘 要 】

The disease called severe acute respiratory syndrome (SARS) is a lifestyle intimidating viral contamination affected by a positive, single stranded novel RNA virus (COVID-2019) from the enveloped coronaviruse family. The COVID-2019 virus has affected many people, scattering promptly, and researchers are attempting to find out medicines for its effectual cure in all over the globe. Chloroquine (ChQ) and its derivatives, an older drug used for the cure of malaria, is exposed to encompass a perceptible feasibility and commendable well-being in opposition to SARS CoV-2 associated pneumonia clinical trials conducted in China. Later on, a few investigations have been directed to find and present SARS CoV-2 antiviral medications. The aim of this present work deals with the potential binding interactions of some imidazolium salts with Nsp9 (Nonstructural protein 9) RNA binding protein of SARS CoV-2.

【 授权许可】

Unknown