Nuances to precision dosing strategies of targeted cancer medicines

Pharmacology Research & Perspectives

Andrew Rowland¹  Michael J. Sorich¹  Ross A. McKinnon¹  Ashley M. Hopkins¹  Ganessan Kichenadasse¹  Howard Gurney²  Bradley D. Menz³  Michael D. Wiese⁴ 

[1] College of Medicine and Public Health Flinders University Adelaide South Australia Australia;Department of Medical Oncology Westmead Hospital Sydney New South Wales Australia;Division of Pharmacy Southern Adelaide Local Health Network, Flinders Medical Centre Adelaide South Australia Australia;School of Pharmacy and Medical Sciences University of South Australia Adelaide South Australia Australia;

关键词: initial dose selection;    on‐therapy dose adaptation;    precision dosing;    prospective studies;    targeted cancer medicines;   

DOI  :  10.1002/prp2.625

来源: DOAJ

【 摘 要 】

Abstract Selecting the dose of a targeted cancer medicine that is most appropriate for a specific individual is a rational approach to maximize therapeutic outcomes and minimize toxicity. There are many different options for optimizing the dose of targeted cancer medicines and the purpose of this review is to provide a comprehensive comparison of the main options explored in prospective studies. Precision initial dose selection of targeted cancer therapies has been minimally explored to date; however, concentration, toxicity, and therapeutic outcome markers are used to guide on‐therapy dose adaption of targeted cancer therapies across several medicines and cancers. While a specific concentration, toxicity, or therapeutic outcome marker commonly dominates an investigated precision on‐therapy dose adaption strategy, greater attention to simultaneously account for exposure, toxicity, therapeutic outcomes, disease status, time since treatment initiation and patient preferences are required for optimal patient outcomes. To enable successful implementation of precision dosing strategies for targeted cancer medicines into clinical practice, future prospective studies aiming to develop strategies should consider these elements in their design.

【 授权许可】

Unknown