Suction‐Cup‐Inspired Adhesive Micromotors for Drug Delivery

Advanced Science

Xiaoyun Qian¹  Lijun Cai¹  Cheng Zhao¹  Renjie Chai¹  Yuanjin Zhao²  Hanxu Chen²  Lu Fan² 

[1] Department of Otolaryngology Head and Neck Surgery Affiliated Drum Tower Hospital of Nanjing University Medical School Jiangsu Provincial Key Medical Discipline Nanjing 210008 China;State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China;

关键词: adhesion;    bio‐inspired;    drug delivery;    hydrogel;    micromotors;    microparticles;   

DOI  :  10.1002/advs.202103384

来源: DOAJ

【 摘 要 】

Abstract Micromotors have opened novel avenues for drug delivery due to their capacity for self‐propelling. Attempts in this field trend towards ameliorating their functions to promote their clinical applications. In this paper, an ingenious suction‐cup‐inspired micromotor is presented with adhesive properties for drug delivery in the stomach. The micromotors are fabricated by using hydrogel replicating the structure of suction‐cup‐like microparticles, which derive from self‐assembly of colloidal crystals under rapid solvent extraction, followed by loading magnesium (Mg) in the bottom spherical surface. The Mg‐loaded micromotors can realize spontaneous movement due to the continual generation of hydrogen bubbles in gastric juice. The combination of unique suction‐cup‐like structure with excellent motion performance makes the micromotor an ideal carrier for drug delivery as they can efficiently adhere to the tissue. Moreover, benefiting from the porous structure, the hydrogel micromotors exhibit a high volume‐surface ratio, which enables efficient drug loading. It is demonstrated that the suction‐cup‐inspired micromotors can adhere efficiently to the ulcer‐region in the stomach and release drugs due to their distinctive architecture and spontaneous motion, exhibiting desirable curative effect of gastric ulcer. Thus, the suction‐cup‐inspired micromotors with adhesive properties are expected to advance the development of micromotor in clinical applications.

【 授权许可】

Unknown