Chemoreactome analysis of 7-hydroxymatairesinol, 17-estradiol, phytoestrogen β-sitosterol and epigallocatechin-3-gallate

Акушерство, гинекология и репродукция

A. N. Rubashkina¹  I. Yu. Torshin²  N. P. Lapochkina³  O. A. Gromova³ 

[1] Big Data Storage and Analysis Center, Lomonosov Moscow State University;Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences;Ivanovo State Medical Academy, Health Ministry of Russian Federation;

关键词: 7-hydroxymatairesinol;    spruce lignans;    17-estradiol;    β-sitosterol phytoestrogen;    epigallocatechin-3-gallate;    chemoreactome analysis;   

DOI  :  10.17749/2313-7347/ob.gyn.rep.2020.152

来源: DOAJ

【 摘 要 】

The results of the evaluation of 7-hydroximatairesinol (7-HMR) properties in comparison with control molecules (17-estradiol, phytoestrogen β-sytostirol, epigallocatechin-3-gallate) are presented. The results of chemoreactomic modeling allowed to formulate the molecular mechanisms of 7-HMR pharmacological effects for anti-inflammatory (inhibition of 5-lipoxygenase, matrix metalloproteinase MMR2, mitogen-activated kinase p38-alpha, leukotriene-b4 receptor, prostacyclin receptor), antitumor (antioxidant effect due to inhibition of hemoxygenase-2, inhibition of cyclin dependent kinases 3 and 4, epidermis growth factor, protein mTOR), vasodilator (inhibition of adrenoreceptors and renin), antibacterial and antiviral (inhibition of viral proteases 3C) properties of 7-HMR molecule.

【 授权许可】

Unknown