Green synthesis of Ag/Fe3O4 nanoparticles using Mentha extract: Preparation, characterization and investigation of its anti-human lung cancer application

Journal of Saudi Chemical Society

Attalla F. El-kott¹  Ghawi J. Majdou²  Abdulrahman A. Alsayegh³  Gaber El-Saber Batiha⁴  Bikash Karmakar⁵  Tao Huang⁶  Huda S. AlSalem⁷  Mona Saad Binkadem⁸  Soha Talal Al-Goul⁹ 

[1] Arts, King Abdulaziz University, Rabigh, Saudi Arabia;Zoology Department, College of Science, Damanhour University, Damanhour, Egypt;Biology Department, College of Science, King Khalid University, Abha, Saudi Arabia;Clinical Nutrition Department, Applied Medical Sciences College, Jazan University, Jazan 82817, Saudi Arabia;Clinical Nutrition Department, General Directorate of Health Affairs, Jazan 82611, Saudi Arabia;Department of Cardiothoracic Surgery, 3201 Hospital, Hanzhong 723000, China;Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia;Department of Chemistry, College of Science, University of Jeddah, P.O. Box 80327, Jeddah 21589, Saudi Arabia;;Department of Chemistry, College of Sciences &

关键词: Ag nanoparticles;    Magnetic nanocomposite;    Green synthesis;    Lung cancer;    Chemotherapeutic supplement;   

DOI  :  

来源: DOAJ

【 摘 要 】

In this study, silver nanoparticles (Ag NPs) were decorated on the surface of magnetic nanoparticles in an eco-friendly pathway applying Mentha extract as reducing/stabilizing agent. The morphological and physicochemical features of the prepared Ag/Fe3O4nanocomposite were determined using several advanced techniques. Hence, our protocol is green and advantageous in terms of- i) biochemical modified biocompatible nanocomposite; ii) nanomaterial providing high surface area and larger number reactive sites; iii) very simplistic synthetic procedure; vi) very low load of metal in the composite and v) high yield in short time. In the medicinal part, the anticancer properties of Ag/Fe3O4 nanocomposite against lung cancer cell lines were determined. The free radical for the antioxidant effects was DPPH. The IC50 of Ag/Fe3O4 nanocomposite was 200 µg/ml in the antioxidant test. The IC50 of the Ag/Fe3O4 nanocomposite were 183, 176, 169, and 125 µg/mL against lung cancer (NCI-H661, NCI-H1975, NCI-H1573, and NCI-H1563) cell lines, respectively. In addition, the current study offer that Ag/Fe3O4 nanocomposite could be a new potential adjuvant chemopreventive and chemotherapeutic agent against cytotoxic cells.

【 授权许可】

Unknown