Preferential Solvation of Fenofibrate in (Ethanol or Acetone) + Water Mixtures at 298.15 K

Iranian Journal of Chemistry & Chemical Engineering

William E. Acree Jr.¹  Fleming Martinez²  Abolghasem Jouyban³ 

[1] Department of Chemistry, University of North Texas, Denton, TX 76203-5070, USA;Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia –Sede Bogotá, Cra. 30 No. 45-03, Bogotá D.C., COLOMBIA;Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, I.R. IRAN+/Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Science, , Tabriz, I.R. IRAN;

关键词: fenofibrate;    cosolvent + water mixtures;    jouyban-acree model;    preferential solvation;    ikbi;   

DOI  :  

来源: DOAJ

【 摘 要 】

The aim of this communication was to expand the results of numerical analyses performed by Sun et al. on their experimental solubility of fenofibrate in aqueous mixtures of ethanol and acetone at 298.15 K, in terms of the evaluation of the preferential solvation of this compound by the organic solvents and water in the saturated mixtures based on the inverse Kirkwood-Buff integrals (IKBI). According to the results, this drug is preferentially solvated by water in water-rich mixtures but preferentially solvated by the cosolvents in mixtures with intermediate composition and also in cosolvent-rich mixtures. Preferential solvation by water in water-rich mixtures may be due to hydrophobic hydration around non-polar moieties of this drug. Moreover, it is conjecturable that in regions with preferential solvation by the cosolvents the drug is acting as Lewis acid with the cosolvent molecules because they are more basic than water.

【 授权许可】

Unknown