Multiple Functions and Mechanisms Underlying the Role of METTL3 in Human Cancers

Frontiers in Oncology

Wenhui Zheng¹  Mingdi Zhang²  Yan Zhao³  Ming Gu³  Haiyang Jiang³  Xiaoshen Dong³  Shuo Wang³  Xinyu Zheng⁴ 

[1] Department of Anesthesiology, The Shengjing Hospital of China Medical University, Shenyang, China;Department of Breast Surgery, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China;Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China;Lab 1, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, China;

关键词: METTL3;    m6A;    cancer;    mechanism;    pathway;   

DOI  :  10.3389/fonc.2019.01403

来源: DOAJ

【 摘 要 】

Methyltransferase-like 3 (METTL3), a predominantly catalytic enzyme in the N6-methyladenosine (m6A) methyltransferase system, is dysregulated and plays a dual role (oncogene or tumor suppressor) in different human cancers. The expression and pro- or anticancer role of METTL3 in different cancers remain controversial. METTL3 is implicated in many aspects of tumor progression, including tumorigenesis, proliferation, invasion, migration, cell cycle, differentiation, and viability. Most underlying mechanisms involve multiple signaling pathways that rely on m6A-dependent modification. However, METTL3 can also modulate the cancer process by directly promoting the translation of oncogenes via interaction with the translation initiation machinery through recruitment of eukaryotic translation initiation factor 3 subunit h (eIF3h). In this review, we summarized the current evidence on METTL3 in diverse human malignancies and its potential as a prognostic/ therapeutic target.

【 授权许可】

Unknown