Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis

Frontiers in Physiology

Mark Potse¹  Mathilde R. Rivaud²  Veronique M. F. Meijborg²  Matthijs Cluitmans²  Bastiaan J. Boukens³  Ruben Coronel⁴  Mélèze Hocini⁴  Nicolas Derval⁴  Michel Haïssaguerre⁴ 

[1] Carmen Team, Inria Bordeaux ‐ Sud-Ouest, Talence, France;Department of Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands;Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands;IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, Bordeaux, France;UMR5251 Institut de mathématiques de Bordeaux, Talence, France;

关键词: idiopathic ventricular fibrillation;    arrhythmias;    early repolarization syndrome;    Purkinje;    ablation;    electrophysiology;   

DOI  :  10.3389/fphys.2021.648396

来源: DOAJ

【 摘 要 】

Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.

【 授权许可】

Unknown