期刊论文详细信息
Frontiers in Physiology
Integrated Metabolomic and Lipidomic Analysis in the Placenta of Preeclampsia
Weinan Deng1  Jingying Liang1  Yingyu Liang1  Shilei Bi1  Lijun Huang1  Shifeng Gu1  Baoying Huang1  Yulian Li1  Minshan Huang1  Lizi Zhang2  Zhijian Wang2  Dunjin Chen3  Jingsi Chen3  Lili Du3 
[1] Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China;Guangdong Engineering and Technology Research Center of Maternal-Fetal Medicine, Guangzhou, China;Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangzhou, China;
关键词: preeclampsia;    metabolomics;    lipidomics;    ultra-high performance chromatography mass spectrometry;    WGCNA;   
DOI  :  10.3389/fphys.2022.807583
来源: DOAJ
【 摘 要 】

Preeclampsia is one of the most common severe pregnancy complications in obstetrics, which is considered a placental source disease. However, the mechanisms underlying preeclampsia remain largely unknown. In this study, UPLC-MS/MS-based metabolomic and lipidomic analysis was used to explore the characteristic placental metabolites in preeclampsia. The results revealed that there were significant changes in metabolites between preeclampsia and normotensive placentas. Weighted correlation network analysis (WGCNA) identified the correlation network module of metabolites highly related to preeclampsia and the clinical traits reflecting disease severity. The metabolic perturbations were primarily associated with glycerophospholipid and glutathione metabolism, which might influent membrane structures of organisms and mitochondria function. Using linear models, three metabolites had an area under receiver operating characteristic curves (AUROC) ≥ 0.80 and three lipids had an AUROC ≥ 0.90. Therefore, metabolomics and lipidomics may offer a novel insight for a better understanding of preeclampsia and provide a useful molecular mechanism underlying preeclampsia.

【 授权许可】

Unknown   

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