Supplementation with grape pomace in healthy women: Changes in biochemical parameters, gut microbiota and related metabolic biomarkers

Journal of Functional Foods

Laura Martín Gómez¹  Miguel Gueimonde¹  M. Victoria Moreno-Arribas²  Begoña Bartolomé²  Alberto Guadarrana³  Marisa Sanz-Buenhombre³  Clara G. de los Reyes-Gavilánc⁴  Nuria Salazar⁴  María Laura García Bermejo⁵  Adelaida Esteban-Fernández⁶  Irene Gil-Sánchez⁶  Dolores González de Llano⁶ 

[1] Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (IISPA), 33011 Asturias, Spain;Biomarkers and Therapeutic Targets Group, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Ctra. de Colmenar Viejo, 28034 Madrid, Spain;Bodega Matarromera, S.L. Ctra. San Bernardo s/n, Valbuena de Duero, 47359 Valladolid, Spain;Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias – Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n Villaviciosa, 33300 Asturias, Spain;Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (IISPA), 33011 Asturias, Spain;Institute of Food Science Research (CIAL), CSIC-UAM, C/ Nicolás Cabrera 9, 28049 Madrid, Spain;

关键词: Grape pomace;    Fasting glucose;    Gut microbiota;    Medium and short fatty acids;    Phenolic metabolites;    microRNAs;   

DOI  :  

来源: DOAJ

【 摘 要 】

This paper reports a comprehensive pilot study of the effects of dietary supplementation with grape pomace (GP) in humans. After an initial washout period, the diet of 10 healthy women was supplemented with a dairy amount of 1.4 g of a red Grape Pomace (GP) extract (Eminol®) for 21 days. Among the different biochemical and immune parameters measured in plasma, a significant decrease (p < 0.05) was observed in blood fasting glucose levels after the 21-day supplementation. Overall, the GP supplementation did not lead to significant changes in faecal bacterial populations or, in general, in the content of faecal and urine phenolic metabolites. Nevertheless, significant changes (p < 0.05) were observed in the short-chain and medium-chain fatty acid profiles (SCFAs and MCFAs). Due to observed inter-individual differences it was not possible to establish a pattern on the microRNA expression profile associated to GP supplementation, however modulation of the expression of miRNA related to glucose metabolism was perceived after the intervention period.

【 授权许可】

Unknown