The Ufm1 Cascade

Cells

Jens Daniel¹  Eva Liebau¹ 

[1] Department of Molecular Physiology, Westfälische Wilhelms-University Münster, Schlossplatz 8,D-48143 Münster, Germany;

关键词: Ufm1;    UBL;    ER stress;    unfolded protein response;   

DOI  :  10.3390/cells3020627

来源: DOAJ

【 摘 要 】

The ubiquitin-fold modifier 1 (Ufm1) is a posttranslational modifier that belongs to the ubiquitin-like protein (UBL) family. Ufm1 is present in nearly all eukaryotic organisms, with the exception of fungi. It resembles ubiquitin in its ability to be ligated to other proteins, as well as in the mechanism of ligation. While the Ufm1 cascade has been implicated in endoplasmic reticulum functions and cell cycle control, its biological role still remains poorly understood. In this short review, we summarize the current state of Ufm1 research and its potential role in human diseases, like diabetes, ischemic heart disease and cancer.

【 授权许可】

Unknown