Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms

Journal of Fungi

Joshua D. Nosanchuk¹  Sirida Youngchim²  Kritsada Pruksaphon²  Kavi Ratanabanangkoon³ 

[1] Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10467, USA;Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand;Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand;

关键词: Talaromyces marneffei;    virulence factors;    macrophages;    immune response;    immune escape;    innate immunity;   

DOI  :  10.3390/jof8020200

来源: DOAJ

【 摘 要 】

Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimorphic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human pathogen and a host’s immune response. This review will highlight the current knowledge regarding the dynamic interaction between T. marneffei and mammalian hosts, particularly highlighting important aspects of virulence factors, intracellular lifestyle and the mechanisms of immune defense as well as the strategies of the pathogen for manipulating and evading host immune cells.

【 授权许可】

Unknown