Lipin proteins and metabolic homeostasis

Journal of Lipid Research

Jennifer R. Dwyer¹  Karen Reue² 

[1] Departments of Human Genetics and Medicine, and Molecular Biology Institute, University of California, Los Angeles, CA 90095;To whom correspondence should be addressed;

关键词: lipodystrophy;    obesity;    triglyceride;    phosphatidate phosphatase;    insulin resistance;   

DOI  :  

来源: DOAJ

【 摘 要 】

The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria, and inflammatory disorders. Here, we review some of the progress toward elucidating the molecular and physiological functions of the lipin proteins.

【 授权许可】

Unknown