Extraintestinal Manifestations of Celiac Disease: Early Detection for Better Long-Term Outcomes

Nutrients

Pilvi Laurikka¹  Samuli Nurminen²  Kalle Kurppa²  Laura Kivelä² 

[1] Celiac Disease Research Center, Faculty of Medicine and Life Sciences, University of Tampere, 33014 Tampere, Finland;Tampere Center for Child Health Research, Tampere University Hospital and University of Tampere, 33014 Tampere, Finland;

关键词: celiac disease;    extraintestinal;    recognition;    diagnosis;    clinical presentation;    gluten-free diet;    prognosis;   

DOI  :  10.3390/nu10081015

来源: DOAJ

【 摘 要 】

Population-based screening studies have shown celiac disease to be one of the most common chronic gastrointestinal diseases. Nevertheless, because of the diverse clinical presentation, the great majority of patients remain unrecognized. Particularly difficult to identify are the multifaceted extraintestinal symptoms that may appear at variable ages. Although the pathogenesis and long-term outcome of these manifestations are still poorly established, there is some evidence that unrecognized celiac disease predisposes to severe complications if not diagnosed and prevented with an early-initiated gluten-free diet. Therefore, it is of utmost importance that physicians of different disciplines learn to recognize celiac disease in individuals with non-gastrointestinal symptoms. In the future, more studies are needed to clarify the factors affecting development and prognosis of the extraintestinal manifestations.

【 授权许可】

Unknown